# Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004)

Source: https://onco.cc/trials/nct06991491/  
OnCo record `nct06991491` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ivonescimab in pancreatic cancer, run by West China Hospital, not yet recruiting.

## Summary

Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004) is a phase 2, interventional study registered as NCT06991491 by West China Hospital, with a registry enrolment figure of 29 participants, started 2025-06-01 and due to reach its primary completion in 2026-06-30. Interventions recorded: GnP in combination with Ivonescimab and SBRT. Conditions listed: Pancreatic Cancer. Primary outcome: 6-month-PFS rate. Pancreatic eligibility wording from the registry: "Patients with pathologically confirmed metastatic pancreatic cancer;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06991491
- Phase: 2
- Setting: Ivonescimab With GnP and SBRT in Patients With Metastatic Pancreatic Cancer (WGOG-PAN 004): an Open-label, Single-arm, Phase II Trial of First-line Multimodal Therapy With Spatial Tumor Immune Microenvironment Analysis
- Sponsor: West China Hospital
- Enrolled: 29

## Sources

- ClinicalTrials.gov NCT06991491: https://clinicaltrials.gov/study/NCT06991491

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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