# Trifluridine/Tipiracil Plus Regorafenib vs Trifluridine/Tipiracil Plus Bevacizumab for Refractory Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct06992648/  
OnCo record `nct06992648` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Second Affiliated Hospital, Zhejiang University, School of Medicine, now recruiting.

## Summary

Trifluridine/Tipiracil Plus Regorafenib vs Trifluridine/Tipiracil Plus Bevacizumab for Refractory Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06992648 by Second Affiliated Hospital, Zhejiang University, School of Medicine, with a registry enrolment figure of 302 participants, started 2025-04-01 and due to reach its primary completion in 2027-12-31. Interventions recorded: Trifluridine/Tipiracil + Regorafenib; Trifluridine/tipiracil + bevacizumab. Conditions listed: Colorectal Cancer Metastatic; Colorectal Cancer Recurrent. Primary outcome: Progression free survival. Colorectal eligibility wording from the registry: "Has histologically confirmed unresectable adenocarcinoma of the colon or rectum (all other histological types are excluded);". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: REGTAS-2
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06992648
- Phase: 3
- Setting: Trifluridine/Tipiracil Plus Regorafenib vs Trifluridine/Tipiracil Plus Bevacizumab for Refractory Metastatic Colorectal Cancer: A Randomized, Controlled, Open-Label, Non-Inferiority Trial
- Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine
- Enrolled: 302

## Sources

- ClinicalTrials.gov NCT06992648: https://clinicaltrials.gov/study/NCT06992648

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06992648.json