# Megestrol Acetate in Improving Neoadjuvant Chemotherapy-Related Weight Loss in Locally Advanced CRC

Source: https://onco.cc/trials/nct06998758/  
OnCo record `nct06998758` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD) in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.

## Summary

Megestrol Acetate in Improving Neoadjuvant Chemotherapy-Related Weight Loss in Locally Advanced CRC is a phase 3, randomised interventional study registered as NCT06998758 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 60 participants, started 2025-11-11 and due to reach its primary completion in 2027-05-10. Interventions recorded: Megestrol Acetate. Conditions listed: Neoadjuvant Chemotherapy; Weight Loss. Primary outcome: Incidence of weight loss. Colorectal eligibility wording from the registry: "* Histologically confirmed colorectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: MATRIX
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06998758
- Phase: 3
- Setting: Megestrol Acetate in Improving Neoadjuvant Chemotherapy-Related Weight Loss in Patients With Locally Advanced Colorectal Cancer: A Multicenter Randomized Controlled Clinical Trial
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT06998758: https://clinicaltrials.gov/study/NCT06998758

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD)](https://onco.cc/drugs/megestrol-progestins/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct06998758.json