# Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

Source: https://onco.cc/trials/nct07006727/  
OnCo record `nct07006727` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1 trial of [225Ac]Ac-ETN029 run by Novartis Pharmaceuticals, now recruiting.

## Summary

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors is a phase 1 interventional study registered as NCT07006727 by Novartis Pharmaceuticals, with 116 participants planned, started 2025-10-16. Conditions recorded: Small Cell Lung Carcinoma, Large Cell Neuroendocrine Carcinoma of the Lung, Neuroendocrine Prostate Cancer, Gastroenteropancreatic Neuroendocrine Carcinoma, Non-prostate Extrapulmonary Neuroendocrine Carcinoma, Cervical Neuroendocrine Carcinoma, Thymic Neuroendocrine Carcinoma, Genitourinary Neuroendocrine Carcinoma, Unknown Primary Neuroendocrine Carcinomas, Merkel Cell Carcinoma and Medullary Thyroid Carcinoma. Interventions recorded: 225Ac-ETN029 and 111In-ETN029.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Registry id: NCT07006727
- Phase: 1
- Setting: A Phase I, Open-label, Multi-center Study to Evaluate the Safety, Tolerability, Dosimetry, and Preliminary Activity of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors
- Sponsor: Novartis Pharmaceuticals
- Enrolled: 116

## Sources

- ClinicalTrials.gov NCT07006727: https://clinicaltrials.gov/study/NCT07006727

## Connected records

- cancers: [Cervical cancer](https://onco.cc/cancers/cervical/), [Extrapulmonary neuroendocrine carcinoma](https://onco.cc/cancers/extrapulmonary-nec/), [Large cell neuroendocrine carcinoma of the lung](https://onco.cc/cancers/lung-lcnec/), [Medullary thyroid cancer](https://onco.cc/cancers/medullary-thyroid-cancer/), [Merkel cell carcinoma](https://onco.cc/cancers/merkel-cell-carcinoma/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [[225Ac]Ac-ETN029](https://onco.cc/drugs/etn029/)
- companies: [Mariana Oncology](https://onco.cc/companies/mariana-oncology/), [Novartis](https://onco.cc/companies/novartis/)

---
JSON: https://onco.cc/api/v1/entities/nct07006727.json