# Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for LARC: PALACE Study

Source: https://onco.cc/trials/nct07020247/  
OnCo record `nct07020247` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by West China Hospital, now recruiting.

## Summary

Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for LARC: PALACE Study is a phase 3, randomised interventional study registered as NCT07020247 by West China Hospital, with a registry enrolment figure of 184 participants, started 2024-11-19 and due to reach its primary completion in 2027-07-31. Interventions recorded: Anti-PD-1 antibody drug named Serplulimab; Radiotherapy; Chemotherapy. Conditions listed: Locally Advanced Rectal Cancer (LARC); Immunotherapy; Radiotherapy; Total Neoadjuvant Therapy; Anal Function Preservation. Primary outcome: Complete response rate. Colorectal eligibility wording from the registry: "Patients with stage II/III rectal cancer staged under MRI or endoscopic ultrasonography and have at least one risk factor: cT4a and invasion of intestinal lumen for more than 1/2 week (measured by MRI)；cT4b(resectable)；cT3c-d with EMVI+ (upper middle rectum)；cN2；MRF+ (≤2mm)；lower rectal cancer is lo". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07020247
- Phase: 3
- Setting: Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for Locally Advanced Rectal Cancer：A Randomized Controlled Study (PALACE Study)
- Sponsor: West China Hospital
- Enrolled: 184

## Sources

- ClinicalTrials.gov NCT07020247: https://clinicaltrials.gov/study/NCT07020247

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07020247.json