# Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT)

Source: https://onco.cc/trials/nct07026422/  
OnCo record `nct07026422` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.

## Summary

Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT) is a phase 2, interventional study registered as NCT07026422 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 54 participants, started 2025-04-30 and due to reach its primary completion in 2026-11-30. Interventions recorded: Total neoadjuvant therapy integrating iparomlimab/tuvonralimab with chemoradiotherapy. Conditions listed: Rectal Malignant Neoplasms. Primary outcome: Overall complete response (CR) rate. Colorectal eligibility wording from the registry: "Histologically confirmed pMMR/MSS rectal adenocarcinoma, defined by MRI as clinical stage II (T3-4, N-) or stage III (any T, N+)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07026422
- Phase: 2
- Setting: Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT): A Single-arm, Exploratory, Phase II Trial
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 54

## Sources

- ClinicalTrials.gov NCT07026422: https://clinicaltrials.gov/study/NCT07026422

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct07026422.json