# Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct07042685/  
OnCo record `nct07042685` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by The Methodist Hospital Research Institute, now recruiting.

## Summary

Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT07042685 by The Methodist Hospital Research Institute, with a registry enrolment figure of 50 participants, started 2026-01-27 and due to reach its primary completion in 2028-12. Interventions recorded: Fruquintinib Combined With Chemotherapy. Conditions listed: Metastatic Colorectal Cancer (CRC). Primary outcome: Time to Progression of 5FU in combination with fruquintinib in first-line metastatic colorectal cancer patients. Colorectal eligibility wording from the registry: "Histopathologically or cytologically confirmed locally advanced unresectable or metastatic colorectal cancer". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07042685
- Phase: 2
- Setting: Phase II Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib as First Line in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer
- Sponsor: The Methodist Hospital Research Institute
- Enrolled: 50

## Sources

- ClinicalTrials.gov NCT07042685: https://clinicaltrials.gov/study/NCT07042685

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07042685.json