# Low Dose Nivolumab With Chemotherapy vs Standard Chemotherapy as First-Line Treatment in Advanced or Metastatic NSCLC

Source: https://onco.cc/trials/nct07050043/  
OnCo record `nct07050043` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Dr Arvindran A/L Alaga, now recruiting.

## Summary

Low Dose Nivolumab With Chemotherapy vs Standard Chemotherapy as First-Line Treatment in Advanced or Metastatic NSCLC is a phase 3, randomised interventional study registered as NCT07050043 by Dr Arvindran A/L Alaga, with a registry enrolment figure of 123 participants, started 2025-05-19 and due to reach its primary completion in 2030-12-31. Interventions recorded: Nivolumab 40mg; Cisplatin, Carboplatin, Pemetrexed, Gemcitabine, Paclitaxel, Docetaxel. Conditions listed: NSCLC (Non-small Cell Lung Carcinoma); First Line Therapy; Locally Advanced/Metastatic NSCLC. Primary outcome: Progression Free Survival (PFS). Lung eligibility wording from the registry: "Histologically confirmed, treatment naïve, locally advanced, or metastatic (stage IIIB - IV (per AJCC version 8), squamous or non-squamous NSCLC with documented PD-L1 expression and is not eligible for definitive chemo-radiation curative therapy and surgery". Sites: Malaysia. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: LEDANG
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07050043
- Phase: 3
- Setting: A Phase III RCT Comparing Low Dose Immunotherapy (Nivolumab) Combined With Standard Chemotherapy vs Standard Chemotherapy as First-line Treatment in Patients With Locally Advanced or Metastatic NSCLC
- Sponsor: Dr Arvindran A/L Alaga
- Enrolled: 123

## Sources

- ClinicalTrials.gov NCT07050043: https://clinicaltrials.gov/study/NCT07050043

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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