# Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

Source: https://onco.cc/trials/nct07064018/  
OnCo record `nct07064018` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of pegfilgrastim and filgrastim (g-csf) in triple-negative breast cancer, run by University of California, Irvine, now recruiting.

## Summary

Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies is a phase 1/2, interventional study registered as NCT07064018 by University of California, Irvine, with a registry enrolment figure of 67 participants, started 2025-04-30 and due to reach its primary completion in 2029-12-31. Interventions recorded: Spedox-6; Pegfilgrastim; Filgrastim. Conditions listed: Soft-tissue Sarcoma; Triple Negative Breast Cancer; Non-small Cell Lung Cancer; Cervical Cancer; Ovarian Cancer; KRAS Mutation-Related Tumors. Triple-negative eligibility wording from the registry: "* Tumor types expected to express lower levels of FcRn relative to normal tissue including: STS, TNBC, cervical cancer, NSCLC, ovarian cancer, and KRAS mutated pancreatic ductal adenocarcinoma without requirement for testing FcRn level". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT07064018
- Phase: 1/2
- Setting: Phase Ib/IIa Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies
- Sponsor: University of California, Irvine
- Enrolled: 67

## Sources

- ClinicalTrials.gov NCT07064018: https://clinicaltrials.gov/study/NCT07064018

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- drugs: [Filgrastim (G-CSF)](https://onco.cc/drugs/filgrastim/), [Pegfilgrastim](https://onco.cc/drugs/pegfilgrastim/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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