# Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer

Source: https://onco.cc/trials/nct07066995/  
OnCo record `nct07066995` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of EB-MF-CAR-NK-01 in pancreatic cancer, run by Essen Biotech, now recruiting.

## Summary

Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer is a phase 1/2, interventional study registered as NCT07066995 by Essen Biotech, with a registry enrolment figure of 60 participants, started 2025-04-29 and due to reach its primary completion in 2027-12-10. Interventions recorded: Mesothelin and Claudin 18.2 CAR-T cells. Conditions listed: Pancreatic Cancer; Pancreatic Carcinoma; Pancreatic Cancer Non-resectable; Pancreatic Cancer Stage IV. Primary outcome: Incidence and severity of dose-limiting toxicities (DLTs) following chemotherapy preparative regimen and infusion of CD19/BCMA chimeric antigen receptor (CAR) T cells. Pancreatic eligibility wording from the registry: "* Histologically or cytologically confirmed pancreatic adenocarcinoma that is advanced (unresectable or metastatic)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: BAH2573-102
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT07066995
- Phase: 1/2
- Setting: Dual-Target Chimeric Antigen Receptor (CAR) T-Cell Therapy Directed Against Mesothelin and Claudin 18.2 in Patients With Advanced or Metastatic Pancreatic Cancer
- Sponsor: Essen Biotech
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT07066995: https://clinicaltrials.gov/study/NCT07066995

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [CAR-T cell therapy](https://onco.cc/technologies/car-t/)
- drugs: [EB-MF-CAR-NK-01](https://onco.cc/drugs/eb-mf-car-nk-01/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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