# Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal Cancer

Source: https://onco.cc/trials/nct07068763/  
OnCo record `nct07068763` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of capecitabine in colorectal cancer, run by Sir Run Run Shaw Hospital, now recruiting.

## Summary

Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal Cancer is a phase 2, interventional study registered as NCT07068763 by Sir Run Run Shaw Hospital, with a registry enrolment figure of 52 participants, started 2025-10-09 and due to reach its primary completion in 2026-12-31. Interventions recorded: Lymph-node-sparing short-course radiotherapy; Capecitabine; PD-1/CTLA-4 inhibitor (Aiparolitoworixureli injection). Conditions listed: Rectal Cancer. Primary outcome: Clinical and pathological complete response rate (CR rate). Colorectal eligibility wording from the registry: "Patients diagnosed with low rectal cancer within 7 cm from the lower edge of the tumor to the anal verge by pelvic MRI and rectal ultrasound, the clinical stage is cT2-3N0M0". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: mRCAT-E
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07068763
- Phase: 2
- Setting: Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Middle and Low Rectal Cancer (mRCAT-E): An Open-label, Single-arm, Prospective Multicenter Clinical Trial
- Sponsor: Sir Run Run Shaw Hospital
- Enrolled: 52

## Sources

- ClinicalTrials.gov NCT07068763: https://clinicaltrials.gov/study/NCT07068763

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07068763.json