# Standard-of-care Systemic Therapy With or Without Local Therapy in Patients With Oligoprogressive Non-Small Cell Lung Cancer(NSCLC）

Source: https://onco.cc/trials/nct07076693/  
OnCo record `nct07076693` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in lung cancer, run by Shanghai Chest Hospital, active but no longer recruiting.

## Summary

Standard-of-care Systemic Therapy With or Without Local Therapy in Patients With Oligoprogressive Non-Small Cell Lung Cancer(NSCLC） is a phase 2/3, randomised interventional study registered as NCT07076693 by Shanghai Chest Hospital, with a registry enrolment figure of 97 participants, started 2025-06-03 and due to reach its primary completion in 2028-05-31. Interventions recorded: Radiotherapy or Surgery; Standard Medical Therapy. Conditions listed: OligoProgressive Metastatic Disease; Non-Small Cell Lung Cancer. Primary outcome: Objective Response Rate (ORR); Progression-free survival (PFS). Lung eligibility wording from the registry: "For Epidermal Growth Factor Receptor (EGFR)-sensitive mutant non-squamous NSCLC patients, first-line treatment must be the third-generation TKIs or progression after first/second-generation TKI without harboring T790M mutation, with ≤3 progressive lesions and ≤3 metastatic organs (PET-CT + cranial M". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07076693
- Phase: 2/3
- Setting: Standard-of-care Systemic Therapy With or Without Local Therapy in Patients With Oligoprogressive NSCLC: A Prospective, Randomized Controlled Phase II/III Clinical Trial
- Sponsor: Shanghai Chest Hospital
- Enrolled: 97

## Sources

- ClinicalTrials.gov NCT07076693: https://clinicaltrials.gov/study/NCT07076693

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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