# A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer

Source: https://onco.cc/trials/nct07078604/  
OnCo record `nct07078604` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of sargramostim in triple-negative breast cancer, run by University of Washington, now recruiting.

## Summary

A Cancer Vaccine (STEMVAC) in Combination With Chemotherapy for the Treatment of PD-L1 Negative Metastatic Triple-Negative Breast Cancer is a phase 2, interventional study registered as NCT07078604 by University of Washington, with a registry enrolment figure of 20 participants, started 2026-03-24 and due to reach its primary completion in 2027-04-30. Interventions recorded: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine; Chemotherapy; Computed Tomography; Sargramostim; Biospecimen Collection; Positron Emission Tomography (PET); Image Guided Biopsy. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma. Triple-negative eligibility wording from the registry: "* Histologically confirmed triple-negative breast cancer". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT07078604
- Phase: 2
- Setting: A Phase II Trial of the Immunogenicity of a DNA Plasmid-Based Vaccine (STEMVAC) Encoding Th1 Selective Epitopes From Five Antigens Associated With Breast Cancer Stem Cells (MDM2, YB1, SOX2, CDH3, CD105) in Patients With Metastatic Triple-Negative Breast Cancer
- Sponsor: University of Washington
- Enrolled: 20

## Sources

- ClinicalTrials.gov NCT07078604: https://clinicaltrials.gov/study/NCT07078604

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- drugs: [Sargramostim](https://onco.cc/drugs/sargramostim/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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