# Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial

Source: https://onco.cc/trials/nct07106034/  
OnCo record `nct07106034` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Shanghai Pudong Hospital, now recruiting.

## Summary

Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial is a phase 2, interventional study registered as NCT07106034 by Shanghai Pudong Hospital, with a registry enrolment figure of 32 participants, started 2025-08-31 and due to reach its primary completion in 2027-07-31. Interventions recorded: Ongericimab + Toripalimab + Bevacizumab + FOLFOX; Ongericimab + Toripalimab + Bevacizumab + FOLFIRI. Conditions listed: Advanced Colorectal Cancer. Primary outcome: overall response rate. Colorectal eligibility wording from the registry: "Histologically confirmed MSS/pMMR colorectal or rectal cancer, who have progressed on first-line fluoropyrimidine - based combination therapy (including progression during maintenance therapy)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: ONTOP
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07106034
- Phase: 2
- Setting: Clinical Study of Second-Line Standard Therapy Combined With Ongericimab and Toripalimab in Patients With MSS/pMMR Colorectal Cancer Following First-Line Treatment Failure
- Sponsor: Shanghai Pudong Hospital
- Enrolled: 32

## Sources

- ClinicalTrials.gov NCT07106034: https://clinicaltrials.gov/study/NCT07106034

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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