# Organoid-guided vs Topotecan Therapy in Relapsed Extensive-Stage Small Cell Lung Cancer

Source: https://onco.cc/trials/nct07106528/  
OnCo record `nct07106528` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of topotecan in lung cancer, run by Peking Union Medical College Hospital, not yet recruiting.

## Summary

Organoid-guided vs Topotecan Therapy in Relapsed Extensive-Stage Small Cell Lung Cancer is a phase 2/3, randomised interventional study registered as NCT07106528 by Peking Union Medical College Hospital, with a registry enrolment figure of 128 participants, started 2025-08 and due to reach its primary completion in 2027-12. Interventions recorded: Organoid Drug Sensitivity Testing-Guided Therapy; Topotecan. Conditions listed: Extensive-stage Small Cell Lung Cancer (ES-SCLC); Extensive-stage Small Cell Lung Cancer (SCLC); Small Cell Lung Cancer ( SCLC ). Primary outcome: Progression-Free Survival (PFS). Lung eligibility wording from the registry: "Pathologically confirmed extensive-stage small cell lung cancer (ES-SCLC) (AJCC 9th edition, Stage IV)". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07106528
- Phase: 2/3
- Setting: Organoid-Based Drug Sensitivity Model Guided Personalized Precision Treatment for Extensive-Stage Small Cell Lung Cancer: A Prospective, Multicenter, Randomized Controlled Trial
- Sponsor: Peking Union Medical College Hospital
- Enrolled: 128

## Sources

- ClinicalTrials.gov NCT07106528: https://clinicaltrials.gov/study/NCT07106528

## Connected records

- cancers: [Extensive-stage small-cell lung cancer](https://onco.cc/cancers/extensive-stage-sclc/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [Topotecan](https://onco.cc/drugs/topotecan/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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