# Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced

Source: https://onco.cc/trials/nct07108127/  
OnCo record `nct07108127` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Peking Union Medical College Hospital, now recruiting.

## Summary

Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced HER2-positive Rectal Cancer is a phase 2, interventional study registered as NCT07108127 by Peking Union Medical College Hospital, with a registry enrolment figure of 24 participants, started 2025-06-20 and due to reach its primary completion in 2026-12-01. Interventions recorded: Trastuzumab biosimilars and pertuzumab biosimilars plus XELOX. Conditions listed: Rectal Cancer; HER2-positive. Primary outcome: CR. Colorectal eligibility wording from the registry: "Patients with rectal cancer confirmed by histology or cytology; locally advanced (cT3/T4, N+, distance from the lower edge of the tumor to the anal verge ≤ 12 cm) rectal adenocarcinoma (using the 8th edition of the AJCC TNM staging);". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NePHera
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07108127
- Phase: 2
- Setting: Phase II Clinical Study on the Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced HER2-positive Rectal Cancer
- Sponsor: Peking Union Medical College Hospital
- Enrolled: 24

## Sources

- ClinicalTrials.gov NCT07108127: https://clinicaltrials.gov/study/NCT07108127

## Connected records

- cancers: [HER2-amplified colorectal cancer](https://onco.cc/cancers/her2-amplified-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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