# A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course R

Source: https://onco.cc/trials/nct07113275/  
OnCo record `nct07113275` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of capecitabine, fOLFOX (5-FU, leucovorin, oxaliplatin) and serplulimab in colorectal cancer, run by Tao Zhang, now recruiting.

## Summary

A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT07113275 by Tao Zhang, with a registry enrolment figure of 444 participants, started 2026-05-15 and due to reach its primary completion in 2028-01-01. Interventions recorded: Short-course radiotherapy; Long-course radiotherapy; Capecitabine; Oxaliplatin; HLX10; TME surgery; HLX10 placebo. Conditions listed: Rectal Cancer; Total Neoadjuvant Therapy; Radiotherapy; Immunotherapy. Primary outcome: 3-year event-Free Survival. Colorectal eligibility wording from the registry: "Histologically confirmed Locally Advanced rectal adenocarcinoma;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07113275
- Phase: 3
- Setting: A National Multicenter, Randomized, Placebo-Controlled Phase III Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer
- Sponsor: Tao Zhang
- Enrolled: 444

## Sources

- ClinicalTrials.gov NCT07113275: https://clinicaltrials.gov/study/NCT07113275

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Serplulimab](https://onco.cc/drugs/serplulimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07113275.json