# Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

Source: https://onco.cc/trials/nct07121595/  
OnCo record `nct07121595` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Carboplatin, Cisplatin, Paclitaxel / nab-paclitaxel, Technetium-99m tilmanocept and Technetium Tc-99m sulfur colloid in Oral cavity cancer, run by University of Michigan Rogel Cancer Center, now recruiting.

## Summary

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial is a phase 2 interventional study registered as NCT07121595 by University of Michigan Rogel Cancer Center, with 50 participants planned, started 2025-07-17 and due to reach its primary completion in 2030-07-01. Interventions recorded: Biospecimen Collection, Carboplatin, Cisplatin, Computed Tomography, Modified Barium Swallow, Paclitaxel, Positron Emission Tomography, Questionnaire Administration, Radiation Therapy, Sentinel Lymph Node Biopsy, Single Photon Emission Computed Tomography, Technetium Tc 99m-labeled Tilmanocept, Technetium Tc-99m Sulfur Colloid. Conditions recorded: Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8, Stage II Lip and Oral Cavity Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8, Stage IVA Lip and Oral Cavity Cancer AJCC v8.

Linked to the drug Technetium Tc-99m sulfur colloid because the registry names it among its interventions and Oral cavity cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT07121595
- Phase: 2
- Setting: PRECEDENT: Pilot Phase II Study of Personalized Radiation to the Contralateral Neck Directed by Sentinel Node Evaluation in Lateralized Oral Cavity Squamous Cell Carcinoma
- Sponsor: University of Michigan Rogel Cancer Center
- Enrolled: 50

## Sources

- ClinicalTrials.gov NCT07121595: https://clinicaltrials.gov/study/NCT07121595

## Connected records

- cancers: [Oral cavity cancer (mouth and tongue)](https://onco.cc/cancers/oral-cavity-cancer/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Technetium Tc-99m sulfur colloid](https://onco.cc/drugs/technetium-sulfur-colloid/), [Technetium-99m tilmanocept](https://onco.cc/drugs/tilmanocept-tc99m/)

---
JSON: https://onco.cc/api/v1/entities/nct07121595.json