# 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemother

Source: https://onco.cc/trials/nct07124884/  
OnCo record `nct07124884` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Federation Francophone de Cancerologie Digestive, not yet recruiting.

## Summary

5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab is a phase 2, interventional study registered as NCT07124884 by Federation Francophone de Cancerologie Digestive, with a registry enrolment figure of 300 participants, started 2025-08-31 and due to reach its primary completion in 2030-06-30. Interventions recorded: Administration of experimental treatment association (sotorasib, panitumumab 5FU). Conditions listed: Colorectal Carcinoma; KRAS G12C Mutation; Unresectable Colorectal Cancer. Primary outcome: Percentage of patient alive or without progression 8 months after inclusion.. Colorectal eligibility wording from the registry: "* Histologically proven advanced-stage unresectable locally advanced or metastatic colorectal adenocarcinoma". Sites: France, Germany, Italy, Spain. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: COLOSOTO
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07124884
- Phase: 2
- Setting: COLOSOTO: Single-arm Phase II Study Evaluating 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab
- Sponsor: Federation Francophone de Cancerologie Digestive
- Enrolled: 300

## Sources

- ClinicalTrials.gov NCT07124884: https://clinicaltrials.gov/study/NCT07124884

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [KRAS G12C-mutant colorectal cancer](https://onco.cc/cancers/kras-g12c-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07124884.json