# Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct07134218/  
OnCo record `nct07134218` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by Changhai Hospital, not yet recruiting.

## Summary

Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer is a phase 2/3, randomised interventional study registered as NCT07134218 by Changhai Hospital, with a registry enrolment figure of 180 participants, started 2025-10 and due to reach its primary completion in 2027-10. Interventions recorded: serplulimab、bevacizumab; neoadjuvant chemoradiation therapy. Conditions listed: Rectal Cancer. Primary outcome: The rate of cCR. Colorectal eligibility wording from the registry: "* Histologically confirmed rectal adenocarcinoma with immunohistochemistry results showing proficient mismatch repair (pMMR) or molecular testing results indicating microsatellite stability (MSS);". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07134218
- Phase: 2/3
- Setting: A National Multicenter, Prospective, Randomized Controlled Study of Serplulimab Injection Combined With Bevacizumab to Improve the Complete Response Rate of Neoadjuvant Therapy for Locally Advanced Stage Intermediate and Low Rectal Cancer
- Sponsor: Changhai Hospital
- Enrolled: 180

## Sources

- ClinicalTrials.gov NCT07134218: https://clinicaltrials.gov/study/NCT07134218

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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