# Lurbinectedin With Osimertinib in Transformed Small Cell Lung Cancer

Source: https://onco.cc/trials/nct07153055/  
OnCo record `nct07153055` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of lurbinectedin and osimertinib in lung cancer, run by Misty Shields, now recruiting.

## Summary

Lurbinectedin With Osimertinib in Transformed Small Cell Lung Cancer is a phase 1/2, interventional study registered as NCT07153055 by Misty Shields, with a registry enrolment figure of 16 participants, started 2026-08 and due to reach its primary completion in 2029-04. Interventions recorded: Lurbinectedin; Osimertinib. Conditions listed: Small Cell Lung Cancer ( SCLC ); Transformed Small Cell Lung Cancer. Primary outcome: Grade 3 or dose-limiting toxicities. Lung eligibility wording from the registry: "Must have a histologically or cytologically confirmed transformation to small cell lung carcinoma/cancer". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: LOTS
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07153055
- Phase: 1/2
- Setting: Phase I/II Trial of Lurbinectedin With Osimertinib in Transformed Small Cell Lung Cancer
- Sponsor: Misty Shields
- Enrolled: 16

## Sources

- ClinicalTrials.gov NCT07153055: https://clinicaltrials.gov/study/NCT07153055

## Connected records

- cancers: [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Lurbinectedin](https://onco.cc/drugs/lurbinectedin/), [Osimertinib](https://onco.cc/drugs/osimertinib/)
- companies: [Jazz Pharmaceuticals](https://onco.cc/companies/jazz/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07153055.json