# Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct07154316/  
OnCo record `nct07154316` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cAPOX (capecitabine, oxaliplatin) and celecoxib in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT07154316 by Fudan University, with a registry enrolment figure of 138 participants, started 2025-08-01 and due to reach its primary completion in 2028-08-01. Interventions recorded: LCRT; SCRT; CAPOX; PD-1; Celecoxib. Conditions listed: Colorectal Cancer. Primary outcome: CR (Complete Response). Colorectal eligibility wording from the registry: "* Pathologically confirmed rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07154316
- Phase: 2
- Setting: A Randomized Phase II Study of Long-term Chemoradiotherapy or Short-term Radiotherapy Combined With CAPOX, PD-1 Monoclonal Antibody and COX-2 Inhibitors in MSS Type Locally Advanced Rectal Cancer
- Sponsor: Fudan University
- Enrolled: 138

## Sources

- ClinicalTrials.gov NCT07154316: https://clinicaltrials.gov/study/NCT07154316

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [Celecoxib](https://onco.cc/drugs/celecoxib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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