# JYP0322 Versus Platinum Based Doublet Chemotherapy in ROS1 Positive Patients Previously Treated With ROS1-TKIs.

Source: https://onco.cc/trials/nct07154368/  
OnCo record `nct07154368` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of pemetrexed in lung cancer, run by Guangzhou JOYO Pharma Co., Ltd, not yet recruiting.

## Summary

JYP0322 Versus Platinum Based Doublet Chemotherapy in ROS1 Positive Patients Previously Treated With ROS1-TKIs. is a phase 3, randomised interventional study registered as NCT07154368 by Guangzhou JOYO Pharma Co., Ltd, with a registry enrolment figure of 207 participants, started 2025-09-23 and due to reach its primary completion in 2027-10-31. Interventions recorded: Pemetrexed injection; Cross-over to JYP0322; JYP0322 tablets. Conditions listed: Non Small Cell Lung Cancer. Primary outcome: Progression Free Survival (PFS) by BICR Assessment. Lung eligibility wording from the registry: "* Subjects with histologically or cytologically documented NSCLC". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07154368
- Phase: 3
- Setting: A Randomized, Open-Label, Multicenter, Phase 3 Study Evaluating the Efficacy and Safety of JYP0322 Versus Platinum-Based Chemotherapy in ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer Patients Previously Treated With ROS1-TKI Therapy.
- Sponsor: Guangzhou JOYO Pharma Co., Ltd
- Enrolled: 207

## Sources

- ClinicalTrials.gov NCT07154368: https://clinicaltrials.gov/study/NCT07154368

## Connected records

- cancers: [ROS1-positive non-small-cell lung cancer](https://onco.cc/cancers/ros1-positive-nsclc/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Pemetrexed](https://onco.cc/drugs/pemetrexed/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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