# Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct07161115/  
OnCo record `nct07161115` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Longhao Li, not yet recruiting.

## Summary

Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT07161115 by Longhao Li, with a registry enrolment figure of 60 participants, started 2025-09-19 and due to reach its primary completion in 2028-08-31. Interventions recorded: Reduced-field short-course radiotherapy; Immunotherapy combined with chemotherapy; Standard short-course radiotherapy; Standard long-course radiotherapy; Chemotherapy. Conditions listed: Rectal Adenocarcinoma. Primary outcome: Two-year local control rate after rectal cancer surgery. Colorectal eligibility wording from the registry: "* Histologically confirmed rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: REFIRT
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07161115
- Phase: 2
- Setting: A Phase II Study Evaluating the Efficacy and Safety of Neoadjuvant Therapy With MRI-Guided Involve-site Short-Course Radiotherapy Combined With Immunotherapy and Chemotherapy for Locally Advanced Rectal Cancer
- Sponsor: Longhao Li
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT07161115: https://clinicaltrials.gov/study/NCT07161115

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07161115.json