# SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer

Source: https://onco.cc/trials/nct07162714/  
OnCo record `nct07162714` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ivonescimab in colorectal cancer, run by Zhejiang Cancer Hospital, now recruiting.

## Summary

SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer is a phase 2, interventional study registered as NCT07162714 by Zhejiang Cancer Hospital, with a registry enrolment figure of 30 participants, started 2025-10-27 and due to reach its primary completion in 2027-03-31. Interventions recorded: radiotherapy; Ivonescimab (20mg/kg Q3W); Non-operative Management; Surgery. Conditions listed: Rectal Cancer; Radiation; AK112. Primary outcome: Complete remission rate (CR rate). Colorectal eligibility wording from the registry: "Histopathologically confirmed rectal adenocarcinoma, without any prior anti - tumor treatment; The status of MMR/MSI is detected by IHC/PCR in pathological biopsy to clarify that the patient's classification is pMMR/MSS;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: STAR
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07162714
- Phase: 2
- Setting: Short-Course Radiotherapy Followed by Ivonescimab (AK112) in pMMR/MSS Mid-Low Rectal Cancer: An Exploratory Phase II Clinical Study.
- Sponsor: Zhejiang Cancer Hospital
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT07162714: https://clinicaltrials.gov/study/NCT07162714

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Ivonescimab](https://onco.cc/drugs/ivonescimab/)
- companies: [Akeso](https://onco.cc/companies/akeso/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07162714.json