# A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation

Source: https://onco.cc/trials/nct07174908/  
OnCo record `nct07174908` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing IN10018 in non-small-cell lung cancer, now recruiting.

## Summary

A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation is a phase 3 interventional study registered as NCT07174908, led by InxMed (Shanghai), and recruiting on the registry. Official title: A Phase 3 Multicenter, Randomised, Controlled, and Open-Label Study of IN10018 in Combination With D-1553 Versus Standard Therapy for the Treatment of First Line Locally-advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation. Planned enrolment is 400 participants (estimated). The study started in 2025-09-10 and primary completion is expected in 2028-09. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Tags: ctgov-ingest
- Registry id: NCT07174908
- Phase: 3
- Setting: A Phase 3 Multicenter, Randomized, Controlled, and Open-Label Study of IN10018 in Combination With D-1553 Versus Standard Therapy for the Treatment of First Line Locally-advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation
- Sponsor: InxMed (Shanghai)
- Enrolled: 400

## Sources

- ClinicalTrials.gov NCT07174908: https://clinicaltrials.gov/study/NCT07174908

## Connected records

- cancers: [KRAS G12C-mutant non-small-cell lung cancer](https://onco.cc/cancers/kras-g12c-nsclc/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [IN10018](https://onco.cc/drugs/in10018/)
- companies: [InxMed](https://onco.cc/companies/inxmed/)

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