# Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression

Source: https://onco.cc/trials/nct07176182/  
OnCo record `nct07176182` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.

## Summary

Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression is a phase 2, randomised interventional study registered as NCT07176182 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 236 participants, started 2026-03-20 and due to reach its primary completion in 2031-03-20. Interventions recorded: mFOLFOX regimen combined with Citrus Flavone Tablets (Alvenor) neoadjuvant treatment group; mFOLFOX regimen neoadjuvant therapy group. Conditions listed: Rectal Cancer Patients; Rectal Cancer Stage II; Rectal Cancer Stage III. Primary outcome: Tumor downstaging rate (to ypTNM stage 0-I). Colorectal eligibility wording from the registry: "Histopathologically confirmed rectal adenocarcinoma; all other histologic subtypes are excluded". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07176182
- Phase: 2
- Setting: mFOLFOX6 Combined With Citrus Flavonoid Tablets (Aimailang) as Neoadjuvant Therapy for Locally Advanced Rectal Cancer With High YWHAB Expression: A Prospective, Multi-center, Open-Label, Randomized Controlled Phase II Clinical Trial
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 236

## Sources

- ClinicalTrials.gov NCT07176182: https://clinicaltrials.gov/study/NCT07176182

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct07176182.json