# NeoAdjuvant Therapy Comparing Sacituzumab Govitecan+Pembrolizumab vs. SoC Chemotherapy in Clinical Stage II-III, Triple-negative Early Breast Cancer

Source: https://onco.cc/trials/nct07178730/  
OnCo record `nct07178730` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of sacituzumab govitecan in triple-negative breast cancer, run by Women's Cancer Study Group GmbH, not yet recruiting.

## Summary

NeoAdjuvant Therapy Comparing Sacituzumab Govitecan+Pembrolizumab vs. SoC Chemotherapy in Clinical Stage II-III, Triple-negative Early Breast Cancer is a phase 3, randomised interventional study registered as NCT07178730 by Women's Cancer Study Group GmbH, with a registry enrolment figure of 765 participants, started 2026-08-30 and due to reach its primary completion in 2033-03-31. Interventions recorded: Sacituzumab govitecan; Pembrolizumab 25 mg/1 ML Intravenous Solution [KEYTRUDA]; SoC Chemotherapy. Conditions listed: Breast Cancer; Triple-negative Breast Cancer. Triple-negative eligibility wording from the registry: "TNBC: ER = 0%, PR = 0%, and HER2- (i". Sites: Germany. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: ADAPT-TN-IV
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT07178730
- Phase: 3
- Setting: NeoAdjuvant Dynamic Marker - Adjusted Personalized Therapy Comparing Sacituzumab Govitecan+Pembrolizumab vs. SoC Chemotherapy in Clinical Stage II-III, Triple-negative Early Breast Cancer
- Sponsor: Women's Cancer Study Group GmbH
- Enrolled: 765

## Sources

- ClinicalTrials.gov NCT07178730: https://clinicaltrials.gov/study/NCT07178730

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/)
- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/)
- drugs: [Sacituzumab govitecan](https://onco.cc/drugs/sacituzumab-govitecan/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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