# Hypofractionated Radiotherapy Combined With NALIRIF, PD-1 Antibody in Locally Recurrent Rectal Cancer(NOVELTY-R)

Source: https://onco.cc/trials/nct07183865/  
OnCo record `nct07183865` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fluorouracil (5-FU), fOLFOX (5-FU, leucovorin, oxaliplatin) and bevacizumab (glioblastoma use) in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Hypofractionated Radiotherapy Combined With NALIRIF, PD-1 Antibody in Locally Recurrent Rectal Cancer(NOVELTY-R) is a phase 2, interventional study registered as NCT07183865 by Fudan University, with a registry enrolment figure of 44 participants, started 2025-03-09 and due to reach its primary completion in 2030-03-09. Interventions recorded: radiotherapy; Irinotecan Hydrochloride Liposome; 5-FU; Leucovorin; SG001; C225; Bevacizumab. Conditions listed: Locally Recurrent Rectal Cancer. Primary outcome: Local objective response rate. Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07183865
- Phase: 2
- Setting: Hypofractionated Radiotherapy Combined With Irinotecan Hydrochloride Liposome, 5-FU, Leucovorin, PD-1 Antibody and Target Therapy in Locally Recurrent Rectal Cancer(NOVELTY-R)
- Sponsor: Fudan University
- Enrolled: 44

## Sources

- ClinicalTrials.gov NCT07183865: https://clinicaltrials.gov/study/NCT07183865

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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