# A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

Source: https://onco.cc/trials/nct07188558/  
OnCo record `nct07188558` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing Rondecabtagene autoleucel in diffuse large B-cell lymphoma and hodgkin lymphoma, now recruiting.

## Summary

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy is a phase 3 interventional study registered as NCT07188558, led by Lyell Immunopharma, and recruiting on the registry. Official title: A Phase 3 Randomised Controlled Trial of Rondecabtagene Autoleucel, an Autologous, Dual-targeting CD19/CD20 CAR T-Cell Product Candidate, Vs. Investigator's Choice of CD19 CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-Cell Lymphoma in the Second-line Setting. Planned enrolment is 400 participants (estimated). The study started in 2026-01-12 and primary completion is expected in 2029-12. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: PiNACLE-H2H
- Tags: ctgov-ingest
- Registry id: NCT07188558
- Phase: 3
- Setting: A Phase 3 Randomized Controlled Trial of Rondecabtagene Autoleucel, an Autologous, Dual-targeting CD19/CD20 CAR T-Cell Product Candidate, Vs. Investigator's Choice of CD19 CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-Cell Lymphoma in the Second-line Setting
- Sponsor: Lyell Immunopharma
- Enrolled: 400

## Sources

- ClinicalTrials.gov NCT07188558: https://clinicaltrials.gov/study/NCT07188558

## Connected records

- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/)
- drugs: [Rondecabtagene autoleucel](https://onco.cc/drugs/rondecabtagene-autoleucel/)
- companies: [Lyell Immunopharma](https://onco.cc/companies/lyell-immunopharma/)

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