# Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.

Source: https://onco.cc/trials/nct07192068/  
OnCo record `nct07192068` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of zanidatamab in colorectal cancer, run by UNICANCER, now recruiting.

## Summary

Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene. is a phase 2, interventional study registered as NCT07192068 by UNICANCER, with a registry enrolment figure of 105 participants, started 2025-10-30 and due to reach its primary completion in 2028-03-13. Interventions recorded: Zanidatamab. Conditions listed: Non-Small Cell Lung Cancer; Sarcoma; Head &Amp; Neck Cancer; Colorectal Carcinoma; Endometrial. Primary outcome: Confirmed Objective Response Rate (ORR) by investigator. Colorectal eligibility wording from the registry: "Histologically or cytologically confirmed endometrial, colorectal, head \& neck, non-small cell lung cancer (NSCLC), or sarcoma". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: AcSé HER2
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07192068
- Phase: 2
- Setting: Widening Treatment Options Among Adult Patients With HER2-overexpressing or Mutant Solid Cancers.
- Sponsor: UNICANCER
- Enrolled: 105

## Sources

- ClinicalTrials.gov NCT07192068: https://clinicaltrials.gov/study/NCT07192068

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [HER2-amplified colorectal cancer](https://onco.cc/cancers/her2-amplified-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Zanidatamab](https://onco.cc/drugs/zanidatamab/)
- companies: [Jazz Pharmaceuticals](https://onco.cc/companies/jazz/), [UNICANCER](https://onco.cc/companies/unicancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07192068.json