# ctDNA-Informed Management of Early-Stage Rectal Cancer

Source: https://onco.cc/trials/nct07209215/  
OnCo record `nct07209215` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by University of California, Davis, not yet recruiting.

## Summary

ctDNA-Informed Management of Early-Stage Rectal Cancer is a phase 2, interventional study registered as NCT07209215 by University of California, Davis, with a registry enrolment figure of 200 participants, started 2026-10 and due to reach its primary completion in 2028-05. Interventions recorded: Signatera Genome ultra-sensitive ctDNA blood test + total neoadjuvant therapy (TNT). Conditions listed: Rectal Adenocarcinoma; Rectal Cancer; Early-stage Rectal Cancer; Locally Advanced Rectal Adenocarcinoma. Primary outcome: Pathologic complete response (pathCR) rate (ctDNA Informed Management Arm); Pathologic complete response (pathCR) rate (Post TNT SOC Surgery Arm); Disease-free survival (DFS) rate (ctDNA Informed Management Arm). Colorectal eligibility wording from the registry: "* Tumor tissue histologically confirming rectal adenocarcinoma that is available for Natera ctDNA assay". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: ULTIMATE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07209215
- Phase: 2
- Setting: ULtra sensiTive ctDNA-Informed Management eArly-stage recTal cancEr (ULTIMATE)
- Sponsor: University of California, Davis
- Enrolled: 200

## Sources

- ClinicalTrials.gov NCT07209215: https://clinicaltrials.gov/study/NCT07209215

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07209215.json