# STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer

Source: https://onco.cc/trials/nct07213570/  
OnCo record `nct07213570` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of regorafenib in colorectal cancer, run by National Cancer Institute, Naples, now recruiting.

## Summary

STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07213570 by National Cancer Institute, Naples, with a registry enrolment figure of 60 participants, started 2025-10-16 and due to reach its primary completion in 2026-10. Interventions recorded: standard second line treatment, at discretion of the investigator; Regorafenib (BAY73-4506). Conditions listed: Colorectal Cancer Metastatic. Primary outcome: Progression Free Survival rate at 6 months in the two arms.. Colorectal eligibility wording from the registry: "Histologically proven of colorectal adenocarcinoma". Sites: Italy. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07213570
- Phase: 2
- Setting: Regorafenib as Second-line Treatment of Patients With RAS-mutant Advanced Colorectal Cancer: a Multicentre, Phase 2 Study
- Sponsor: National Cancer Institute, Naples
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT07213570: https://clinicaltrials.gov/study/NCT07213570

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Regorafenib](https://onco.cc/drugs/regorafenib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07213570.json