# Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized,

Source: https://onco.cc/trials/nct07230639/  
OnCo record `nct07230639` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.

## Summary

Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial is a phase 2, randomised interventional study registered as NCT07230639 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 52 participants, started 2025-08-30 and due to reach its primary completion in 2030-08-29. Interventions recorded: Node-Sparing Radiotherapy(25Gy/5F) plus Chemotherapy and PD-1 inhibitor; Node-Sparing Radiotherapy(24Gy/4F) plus Chemotherapy and PD-1 inhibitor. Conditions listed: Neoadjuvant Therapies; Immune Checkpoint Therapy; Radiotherapy. Primary outcome: Pathological Complete Response(pCR) Rate. Colorectal eligibility wording from the registry: "Histologically confirmed colon adenocarcinoma (without squamous or sarcomatoid components)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: MODIFI-CC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07230639
- Phase: 2
- Setting: Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 52

## Sources

- ClinicalTrials.gov NCT07230639: https://clinicaltrials.gov/study/NCT07230639

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct07230639.json