# Firstline Sequential AG and mFOLFOX Combined With Serplulimab and Bevacizumab Versus AG Chemotherapy Alone in Advanced Pancreatic Cancer

Source: https://onco.cc/trials/nct07235930/  
OnCo record `nct07235930` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of bevacizumab and gemcitabine + nab-paclitaxel in pancreatic cancer, run by Zhejiang Cancer Hospital, now recruiting.

## Summary

Firstline Sequential AG and mFOLFOX Combined With Serplulimab and Bevacizumab Versus AG Chemotherapy Alone in Advanced Pancreatic Cancer is a phase 3, randomised interventional study registered as NCT07235930 by Zhejiang Cancer Hospital, with a registry enrolment figure of 292 participants, started 2025-11-15 and due to reach its primary completion in 2029-07-01. Interventions recorded: Sequential AG and mFOLFOX in Combination With Serplulimab and Bevacizumab; AG chemotherapy. Conditions listed: Non-Resectable Pancreas Carcinoma. Primary outcome: Overall survival (OS). Pancreatic eligibility wording from the registry: "Pancreatic ductal adenocarcinoma confirmed by pathologic histology or cytology;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT07235930
- Phase: 3
- Setting: Nab-Paclitaxel/Gemcitabine Followed by mFOLFOX Combined With Serplulimab and Bevacizumab Versus AG Chemotherapy Alone in Previously Untreated Advanced Pancreatic Cancer: A Randomized, Controlled, Multicenter Phase III Trial
- Sponsor: Zhejiang Cancer Hospital
- Enrolled: 292

## Sources

- ClinicalTrials.gov NCT07235930: https://clinicaltrials.gov/study/NCT07235930

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Bevacizumab](https://onco.cc/drugs/bevacizumab/), [Gemcitabine + nab-paclitaxel](https://onco.cc/drugs/gemcitabine-nab-paclitaxel/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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