# A Pilot Study Evaluating β-hydroxybutyrate Supplementation Concomitant to Short-Course Radiotherapy Followed by Immunotherapy Combined With CAPEOX Neoadjuvant T

Source: https://onco.cc/trials/nct07239466/  
OnCo record `nct07239466` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of capecitabine and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Tao Zhang, now recruiting.

## Summary

A Pilot Study Evaluating β-hydroxybutyrate Supplementation Concomitant to Short-Course Radiotherapy Followed by Immunotherapy Combined With CAPEOX Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07239466 by Tao Zhang, with a registry enrolment figure of 25 participants, started 2026-01-01 and due to reach its primary completion in 2026-12-31. Interventions recorded: Short-course radiotherapy; Capecitabine; Oxaliplatin; TME surgery; β-hydroxybutyrate. Conditions listed: Rectal Cancer; Radiotherapy; Immunotherapy; Chemotherapy. Primary outcome: complete response (CR) rate. Colorectal eligibility wording from the registry: "Histologically confirmed Locally Advanced rectal adenocarcinoma;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07239466
- Phase: 2
- Setting: A Single-Arm, Single-Center Study of Exploring the β-hydroxybutyrate Supplementation and Short-Course Radiotherapy Followed by Immunotherapy Combined With CAPEOX Neoadjuvant Therapy in Locally Advanced Rectal Cancer
- Sponsor: Tao Zhang
- Enrolled: 25

## Sources

- ClinicalTrials.gov NCT07239466: https://clinicaltrials.gov/study/NCT07239466

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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