# Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)

Source: https://onco.cc/trials/nct07243938/  
OnCo record `nct07243938` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of zanidatamab, capecitabine and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Tao Zhang, not yet recruiting.

## Summary

Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET) is a phase 2, interventional study registered as NCT07243938 by Tao Zhang, with a registry enrolment figure of 70 participants, started 2026-01-15 and due to reach its primary completion in 2028-07-30. Interventions recorded: short-course radiotherapy; Zanidatamab; Tisleizumab(BGB-A317); Capecitabine; Oxaliplatin; TME surgery; S-1; D2. Conditions listed: Locally Advanced Rectal Cancer (LARC); Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma; Metastatic Colorectal Cancer (mCRC); Neoadjuvant Therapy. Primary outcome: Complete Response Rate (CR Rate); Pathological Complete Response Rate (pCR Rate); Progression-Free Survival (PFS). Colorectal eligibility wording from the registry: "* Clinical diagnosis of gastric cancer and colorectal cancer". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07243938
- Phase: 2
- Setting: A Prospective, Multi-cohort Clinical Study to Explore the Preliminary Efficacy and Safety of Zanidatamab in Combination With Tislelizumab for HER2-Positive GI Tumors: the UNION-HER2-BASKET Study
- Sponsor: Tao Zhang
- Enrolled: 70

## Sources

- ClinicalTrials.gov NCT07243938: https://clinicaltrials.gov/study/NCT07243938

## Connected records

- cancers: [HER2-amplified colorectal cancer](https://onco.cc/cancers/her2-amplified-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Zanidatamab](https://onco.cc/drugs/zanidatamab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct07243938.json