# A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Rectal Cancer: Integrated Clinical and Translational

Source: https://onco.cc/trials/nct07248020/  
OnCo record `nct07248020` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Chang Gung Memorial Hospital, not yet recruiting.

## Summary

A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Rectal Cancer: Integrated Clinical and Translational Analysis of Tumor Tissue is a phase 2, interventional study registered as NCT07248020 by Chang Gung Memorial Hospital, with a registry enrolment figure of 72 participants, started 2026-01-01 and due to reach its primary completion in 2028-12-31. Interventions recorded: Curcumin (BCM-95®). Conditions listed: Rectal Cancer; Locally Advanced Rectal Cancer; Radiation-Induced Enteritis; Radiation Proctitis; Chemoradiotherapy-Related Toxicity. Primary outcome: Incidence of Grade ≥3 Gastrointestinal Toxicity (Enteritis or Proctitis) During Neoadjuvant Chemoradiotherapy. Colorectal eligibility wording from the registry: "(A) Males and females more than 20 years of age (B) Signed informed consent (C) Patients with a pathologically proven rectal adenocarcinoma located less than 10 cm to the anus". Sites: Taiwan. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: BCMRECRAD
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07248020
- Phase: 2
- Setting: A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Rectal Cancer: Integrated Clinical and Translational Analysis of Tumor Tissue
- Sponsor: Chang Gung Memorial Hospital
- Enrolled: 72

## Sources

- ClinicalTrials.gov NCT07248020: https://clinicaltrials.gov/study/NCT07248020

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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