# A Phase II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Subjects With Advanced Lung Cancer

Source: https://onco.cc/trials/nct07253142/  
OnCo record `nct07253142` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Serplulimab in non-small-cell lung cancer and small-cell lung cancer, run by Shanghai Henlius Biotech, now recruiting.

## Summary

A Phase II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Subjects With Advanced Lung Cancer is a phase 2 interventional study registered as NCT07253142 by Shanghai Henlius Biotech, with 120 participants planned, started 2026-02-05 and due to reach its primary completion in 2027-06-18. Interventions recorded: HLX43 dose 1, HLX43 dose 2. Conditions listed: Non Small Cell Lung Cancer, Small Cell Lung Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT07253142
- Phase: 2
- Setting: A Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX43 (Anti-PD-L1 ADC) in Combination With Serplulimab (Humanized Anti-PD-1 Monoclonal Antibody Injection) in Advanced Stage Lung Cancer
- Sponsor: Shanghai Henlius Biotech
- Enrolled: 120

## Sources

- ClinicalTrials.gov NCT07253142: https://clinicaltrials.gov/study/NCT07253142

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Serplulimab](https://onco.cc/drugs/serplulimab/)
- companies: [Shanghai Henlius Biotech](https://onco.cc/companies/henlius/)

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JSON: https://onco.cc/api/v1/entities/nct07253142.json