# The Safety and Efficacy of Cetuximab Beta Plus Fruquintinib With or Without Immune Checkpoint Inhibitorrs in First-line Treatment of RAS/BRAF Wild Type Unresect

Source: https://onco.cc/trials/nct07257653/  
OnCo record `nct07257653` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Zhejiang University, now recruiting.

## Summary

The Safety and Efficacy of Cetuximab Beta Plus Fruquintinib With or Without Immune Checkpoint Inhibitorrs in First-line Treatment of RAS/BRAF Wild Type Unresectable Metastatic Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07257653 by Zhejiang University, with a registry enrolment figure of 70 participants, started 2025-10-21 and due to reach its primary completion in 2026-12-31. Interventions recorded: Cetuximab β；Fruquintinib；; Cetuximab β；Fruquintinib；anti-PD1 antibody；; Cetuximab β；Fruquintinib；anti-PD1/CTLA4 antibody. Conditions listed: Colorectal Neoplasms; RAS; BRAF; Cetuximabβ; Fruquintinib. Primary outcome: PFS. Colorectal eligibility wording from the registry: "For patients aged 80-85, comprehensive functional assessments must be completed, and they may be enrolled if the investigator deems them tolerable, with an expected survival of over 3 months; 3) Histopathologically and/or cytologically confirmed, unresectable metastatic colorectal adenocarcinoma con". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: concept
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07257653
- Phase: 2
- Setting: The Safety and Efficacy of Cetuximab Beta Plus Fruquintinib With or Without Immune Checkpoint Inhibitorrs in First-line Treatment of RAS/BRAF Wild Type Unresectable Metastatic Colorectal Cancer
- Sponsor: Zhejiang University
- Enrolled: 70

## Sources

- ClinicalTrials.gov NCT07257653: https://clinicaltrials.gov/study/NCT07257653

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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