# EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Partic

Source: https://onco.cc/trials/nct07262619/  
OnCo record `nct07262619` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Pembrolizumab in colorectal cancer and endometrial cancer, run by Eikon Therapeutics, now recruiting.

## Summary

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors is a phase 1/2 interventional study registered as NCT07262619 by Eikon Therapeutics, with 160 participants planned, started 2026-01-20 and due to reach its primary completion in 2029-03. Interventions recorded: EIK1005, pembrolizumab (KEYTRUDA® ). Conditions listed: Advanced Solid Tumors, MSI-H or dMMR Advanced Solid Tumors, MSI-H/dMMR Gastric Cancer, MSI-H/dMMR Colorectal Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT07262619
- Phase: 1/2
- Setting: A Multicenter, Multi-Part, Phase 1/2 Study of EIK1005 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors, Including Checkpoint Inhibitor Naïve Participants With Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) Tumors
- Sponsor: Eikon Therapeutics
- Enrolled: 160

## Sources

- ClinicalTrials.gov NCT07262619: https://clinicaltrials.gov/study/NCT07262619

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Endometrial cancer](https://onco.cc/cancers/endometrial/)
- drugs: [EIK1005](https://onco.cc/drugs/eik1005/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- companies: [Eikon Therapeutics](https://onco.cc/companies/eikon-therapeutics/)

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