# TREND-02 - a Phase II Exploratory De-escalation Trial of Neoadjuvant Sacituzumab Govitecan Plus Tislelizumab (SG/I) in Early Triple-negative Breast Cancer

Source: https://onco.cc/trials/nct07271992/  
OnCo record `nct07271992` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of sacituzumab govitecan in triple-negative breast cancer, run by First Hospital of China Medical University, not yet recruiting.

## Summary

TREND-02 - a Phase II Exploratory De-escalation Trial of Neoadjuvant Sacituzumab Govitecan Plus Tislelizumab (SG/I) in Early Triple-negative Breast Cancer is a phase 2, interventional study registered as NCT07271992 by First Hospital of China Medical University, with a registry enrolment figure of 30 participants, started 2025-12-15 and due to reach its primary completion in 2030-12-14. Interventions recorded: SG+I. Conditions listed: TNBC, Triple Negative Breast Cancer. Triple-negative eligibility wording from the registry: "Histologically confirmed stage II or III primary invasive TNBC TNBC defined as: immunohistochemistry (IHC) ER and PR \<1%; HER2-negative, IHC 0 or 1+, IHC 2+, ISH-; 3". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: TREND-02
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT07271992
- Phase: 2
- Setting: TREND-02 - a Phase II Exploratory De-escalation Trial of Neoadjuvant Sacituzumab Govitecan Plus Tislelizumab (SG/I) in Early Triple-negative Breast Cancer
- Sponsor: First Hospital of China Medical University
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT07271992: https://clinicaltrials.gov/study/NCT07271992

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/)
- technologies: [Antibody-drug conjugate (ADC)](https://onco.cc/technologies/adc/)
- drugs: [Sacituzumab govitecan](https://onco.cc/drugs/sacituzumab-govitecan/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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