# Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases

Source: https://onco.cc/trials/nct07277322/  
OnCo record `nct07277322` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of toripalimab in colorectal cancer, run by Dan Feng, now recruiting.

## Summary

Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases is a phase 1/2, interventional study registered as NCT07277322 by Dan Feng, with a registry enrolment figure of 24 participants, started 2026-09-01 and due to reach its primary completion in 2028-12-31. Interventions recorded: Dupilumab; Toripalimab. Conditions listed: Metastatic Colorectal Cancer; Liver Metastases. Primary outcome: Number of dose limiting toxicities (DLTs). Colorectal eligibility wording from the registry: "* Has not undergone a hysterectomy or bilateral oophorectomy; or". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07277322
- Phase: 1/2
- Setting: Master Protocol for A Phase 1b/2 Study of Neoadjuvant Immunotherapy in Microsatellite Stable (MSS) Colorectal Cancer (CRC) Subjects With Resectable Liver Metastases
- Sponsor: Dan Feng
- Enrolled: 24

## Sources

- ClinicalTrials.gov NCT07277322: https://clinicaltrials.gov/study/NCT07277322

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Toripalimab](https://onco.cc/drugs/toripalimab/)
- companies: [Coherus BioSciences](https://onco.cc/companies/coherus/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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