# PD-1 + FOLFOXIRI vs CAPOX as Total Neoadjuvant Therapy for pMMR Low Rectal Cancer

Source: https://onco.cc/trials/nct07277842/  
OnCo record `nct07277842` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of serplulimab in colorectal cancer, run by Sun Yat-sen University, not yet recruiting.

## Summary

PD-1 + FOLFOXIRI vs CAPOX as Total Neoadjuvant Therapy for pMMR Low Rectal Cancer is a phase 3, randomised interventional study registered as NCT07277842 by Sun Yat-sen University, with a registry enrolment figure of 382 participants, started 2025-12-29 and due to reach its primary completion in 2028-12-29. Interventions recorded: Serplulimab; FOLFOXIRI chemotherapy; CAPOX chemotherapy; Long-course pelvic radiotherapy. Conditions listed: Locally Advanced Low Rectal Adenocarcinoma; pMMR (Microsatellite Stable Rectal Cancer). Primary outcome: 3-year Event-Free Survival (EFS). Colorectal eligibility wording from the registry: "* Histologically confirmed rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07277842
- Phase: 3
- Setting: A Multicenter, Prospective, Phase III Randomized Controlled Trial of PD-1 Antibody Plus FOLFOXIRI Combined With Radiotherapy Versus CAPOX Combined With Radiotherapy as Total Neoadjuvant Therapy for pMMR Locally Advanced Low Rectal Cancer
- Sponsor: Sun Yat-sen University
- Enrolled: 382

## Sources

- ClinicalTrials.gov NCT07277842: https://clinicaltrials.gov/study/NCT07277842

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Serplulimab](https://onco.cc/drugs/serplulimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07277842.json