# Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic MSS CRC

Source: https://onco.cc/trials/nct07281716/  
OnCo record `nct07281716` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of toripalimab in colorectal cancer, run by Dan Feng, now recruiting.

## Summary

Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic MSS CRC is a phase 1/2, interventional study registered as NCT07281716 by Dan Feng, with a registry enrolment figure of 24 participants, started 2025-12-01 and due to reach its primary completion in 2028-12-15. Interventions recorded: Nadunolimab; Toripalimab. Conditions listed: Metastatic Microsatellite Stable Colorectal Carcinoma. Primary outcome: Dose-Limiting Toxicities (DLTs); Objective Response Rate (ORR). Colorectal eligibility wording from the registry: "A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: o Has not undergone a hysterectomy or bilateral oophorectomy; or o Has not been naturally postmenopausal for at le". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07281716
- Phase: 1/2
- Setting: A Phase 1b/2 Study of Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC)
- Sponsor: Dan Feng
- Enrolled: 24

## Sources

- ClinicalTrials.gov NCT07281716: https://clinicaltrials.gov/study/NCT07281716

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Toripalimab](https://onco.cc/drugs/toripalimab/)
- companies: [Coherus BioSciences](https://onco.cc/companies/coherus/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07281716.json