# Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation

Source: https://onco.cc/trials/nct07292298/  
OnCo record `nct07292298` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by University of Colorado, Denver, now recruiting.

## Summary

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates is a phase 2, interventional study registered as NCT07292298 by University of Colorado, Denver, with a registry enrolment figure of 44 participants, started 2026-11 and due to reach its primary completion in 2030-11. Interventions recorded: High Rare Dose Rectal Brachytherapy Boost. Conditions listed: Rectal Adenocarcinoma; Rectal Cancer. Primary outcome: Organ preservation (no surgical requirement) of the rectum associated with complete clinical response. Colorectal eligibility wording from the registry: "Patients with MMR-proficient low-mid rectal adenocarcinoma cT1-4 N0-2 M0 who underwent total neoadjuvant therapy who have not achieved complete response (i". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07292298
- Phase: 2
- Setting: Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- Sponsor: University of Colorado, Denver
- Enrolled: 44

## Sources

- ClinicalTrials.gov NCT07292298: https://clinicaltrials.gov/study/NCT07292298

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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