# Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer

Source: https://onco.cc/trials/nct07314528/  
OnCo record `nct07314528` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by St. James's Hospital, Ireland, not yet recruiting.

## Summary

Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer is a phase 2, randomised interventional study registered as NCT07314528 by St. James's Hospital, Ireland, with a registry enrolment figure of 42 participants, started 2026-04 and due to reach its primary completion in 2028-09. Interventions recorded: GLP-1 receptor agonist; Total neoadjuvant therapy (TNT). Conditions listed: Rectal Cancer Patients; Obesity &Amp; Overweight; Locally Advanced Rectal Cancer (LARC); Total Neoadjuvant Therapy; GLP-1. Primary outcome: Weight Loss; Metabolic Profile of the Tissue; Inflammatory Mediators. Colorectal eligibility wording from the registry: "* Histologically confirmed mismatch repair protein proficient adenocarcinoma of the rectum". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07314528
- Phase: 2
- Setting: A Phase II Multi-institutional Randomized Trial Evaluating the Impact of GLP-1 Receptor Agonists in Combination With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer
- Sponsor: St. James's Hospital, Ireland
- Enrolled: 42

## Sources

- ClinicalTrials.gov NCT07314528: https://clinicaltrials.gov/study/NCT07314528

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07314528.json