# Injection of IP-001 Into Thermally Ablated Hepatic Tumors in Patients With Colorectal Liver Metastases

Source: https://onco.cc/trials/nct07321847/  
OnCo record `nct07321847` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by Immunophotonics, Inc., not yet recruiting.

## Summary

Injection of IP-001 Into Thermally Ablated Hepatic Tumors in Patients With Colorectal Liver Metastases is a phase 2/3, randomised interventional study registered as NCT07321847 by Immunophotonics, Inc., with a registry enrolment figure of 717 participants, started 2026-05 and due to reach its primary completion in 2033-12. Interventions recorded: 1.0% IP-001 for Injection, a 10 mg/mL solution of IP-001 in water; 1.0% IP-001 for Injection, a 1 mg/mL solution of IP-001 in water.; Microwave (thermal) tumor ablation. Conditions listed: Colorectal Cancer (CRC); Colon Cancer Liver Metastases; Rectal Cancer; Rectal Cancer With Liver Metastases; Colorectal Liver Metastasis (CRLM). Primary outcome: To compare the efficacy of IP-001 following standard-of-care (SOC) complete hepatic tumor ablation vs SOC complete hepatic tumor ablation alone in prolonging progression-free survival. Colorectal eligibility wording from the registry: "No residual primary colorectal tumor at Treatment Day 1 or plans to have the primary tumor excised within 4-12 weeks following Treatment Day 1". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: INJECTABL-3
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07321847
- Phase: 2/3
- Setting: Intratumoral Injection of IP-001 Following Standard-of-care Complete Hepatic Tumor Ablation in Patients With Liver-only Metastatic Colorectal Cancer
- Sponsor: Immunophotonics, Inc.
- Enrolled: 717

## Sources

- ClinicalTrials.gov NCT07321847: https://clinicaltrials.gov/study/NCT07321847

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Thermal ablation (RFA, microwave, cryo)](https://onco.cc/technologies/thermal-ablation/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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