# Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

Source: https://onco.cc/trials/nct07340541/  
OnCo record `nct07340541` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of abemaciclib, everolimus and capecitabine in triple-negative breast cancer, run by UNC Lineberger Comprehensive Cancer Center, now recruiting.

## Summary

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies is a phase 2, interventional study registered as NCT07340541 by UNC Lineberger Comprehensive Cancer Center, with a registry enrolment figure of 700 participants, started 2026-02-16 and due to reach its primary completion in 2031-06-02. Interventions recorded: SERD* + abemaciclib; SERD* + everolimus; SERD* + everolimus or capecitabine; SOC; Antiandrogen. Conditions listed: Breast Cancer; Metastatic Breast Cancer; Triple Negative Breast Cancer; Estrogen-receptor-positive Breast Cancer; Hormone Receptor Negative Breast Carcinoma. Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: EVOLVE-BDT
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT07340541
- Phase: 2
- Setting: TBCRC Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies (EVOLVE-BDT)
- Sponsor: UNC Lineberger Comprehensive Cancer Center
- Enrolled: 700

## Sources

- ClinicalTrials.gov NCT07340541: https://clinicaltrials.gov/study/NCT07340541

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Abemaciclib](https://onco.cc/drugs/abemaciclib/), [Capecitabine](https://onco.cc/drugs/capecitabine/), [Everolimus](https://onco.cc/drugs/everolimus/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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