# Phase Ib/II Study to Evaluate the Safety and Efficacy of IBI363 in Combination With Chemotherapy as Second-Line Therapy for Unresectable Locally Advanced or Met

Source: https://onco.cc/trials/nct07342725/  
OnCo record `nct07342725` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of IBI363 in pancreatic cancer, run by Ruijin Hospital, not yet recruiting.

## Summary

Phase Ib/II Study to Evaluate the Safety and Efficacy of IBI363 in Combination With Chemotherapy as Second-Line Therapy for Unresectable Locally Advanced or Metastatic Pancreatic Cancer is a phase 1/2, interventional study registered as NCT07342725 by Ruijin Hospital, with a registry enrolment figure of 48 participants, started 2026-01-01 and due to reach its primary completion in 2027-12-31. Interventions recorded: IBI363 + chemotherapy. Conditions listed: Pancreatic Cancer Metastatic. Primary outcome: Adverse events (AEs); Progression-Free Survival(PFS). Pancreatic eligibility wording from the registry: "* Histologically/cytologically confirmed, unresectable locally advanced or metastatic pancreatic cancer". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT07342725
- Phase: 1/2
- Setting: Phase Ib/II Study to Evaluate the Safety and Efficacy of IBI363 in Combination With Chemotherapy as Second-Line Therapy for Unresectable Locally Advanced or Metastatic Pancreatic Cancer
- Sponsor: Ruijin Hospital
- Enrolled: 48

## Sources

- ClinicalTrials.gov NCT07342725: https://clinicaltrials.gov/study/NCT07342725

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- drugs: [IBI363](https://onco.cc/drugs/ibi363/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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